Identification of fibronectin 1 as a candidate genetic modifier in a Col4a1 mutant mouse model of Gould syndrome.

Dis Model Mech · 2021 · PMC8106953 · PMID 34424299

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showed a trendno p-value reported

In a parallel experiment, we tested the effect of this congenic locus on myopathy and observed a dosage effect, whereby Col4a1 +/Δex41 mice that were heterozygous at the MoGS1 locus ( MoGS1 C/B ) showed a trend toward reduced myopathy, while homozygous MoGS1 C/C incipient congenic mice had significantly milder myopathy compared to mice that were homozygous for the B6 allele ( MoGS1 B/B ).

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