Increased excitatory to inhibitory synaptic ratio in parietal cortex samples from individuals with Alzheimer's disease.

However, within layer 2 this ratio was significantly larger in the AD group as compared to controls (Welch ANOVA, P = 0.0316; followed by Dunn post hoc test comparing AD and DS vs control); the DS group had a trend in the same direction for layer 2 but this effect did not reach statistical significance due to greater group spread (Fig. 3b ).

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