Checkpoint-blocker-induced autoimmunity is associated with favourable outcome in metastatic melanoma and distinct T-cell expression profiles.

Importantly, we replicated these observations in an independent cohort, with treatment-specific analysis showing the effect being highly significant in recipients of cICB, and a non-significant directional trend in the sICB group.

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Pathway analysis was performed in XGR 20 with the GOBP dataset,“elim” algorithm and hypergeometric test across all nominally significant (FDR < 0.5) genes.

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