Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).

Mol Brain · 2021 · PMC8111776 · PMID 33971917

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showed a trendno p-value reported

gba2 KO medaka showed a trend towards an increase in sphingolipids in the brains, which is one of the possible causes of asyn accumulation.

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an increasing trendno p-value reported

In summary, compared with gba1 KO medaka, gba1/gba2 DKO medaka showed a significant increase in GlcCer and GlcSph, and an increasing trend in sphingosine and GalSph in the brains.

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