Cell-Type Specific Changes in DNA Methylation of <i>SNCA</i> Intron 1 in Synucleinopathy Brains.

Front Neurosci · 2021 · PMC8113398 · PMID 33994928

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a suggestive trendno p-value reported

The glial cell population showed no significant differences in the overall DNA methylation levels in this region between all three neuropathological groups, although DLB glia exhibited a suggestive trend of overall decreased methylation ( Figure 5D ).

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borderline significantno p-value reported

While the analysis of the neuronal nuclei showed no significant differences in the overall DNA methylation level between the DLB and the control groups, borderline significant lower overall DNA methylation levels were observed in neuronal nuclei from PD subjects compared to control ( p t –test < 0.05, p Dunnett = 0.08, Figure 5B ).

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