REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study.

Front Pharmacol · 2021 · PMC8113752 · PMID 33995104

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did not reach statistical significanceno p-value reported

highly significantno p-value reported

While the decrease in systolic BP did not reach statistical significance ( Figure 2A ), a highly significant decrease in diastolic BP was evident in REL-1017 vs. placebo subjects ( Figure 2B ), both at 2 and 24 h after drug administration.

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