Compartmentalization of cerebrospinal fluid inflammation across the spectrum of untreated HIV-1 infection, central nervous system injury and viral suppression.

Residual CSF biomarker elevations in the ART- suppressed groups included TNFα, CXCL10, sCD14, sCD163 and sVCAM-1, while several others showed elevations that did not reach statistical significance.

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Seven of these concentration differences were highly significant, the exceptions being TNFα, with high variability in the sample, and both neopterin and IL-6 with CSF concentrations that were close to those in blood.

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