Moreover, higher hRNase 1 expression significantly correlated with poorer survival in tumors with grade 2 in a near-significant trend (Fig. 1b ), and hRNase 1 appeared to be a more significant poor prognostic factor in breast cancer patients with lymph node (LN)-negative non-metastasis, compared with those with LN-positive metastasis (Fig. 1c ).
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Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.
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