SGLT2 inhibitors and lower limb complications: the diuretic-induced hypovolemia hypothesis.

Cardiovasc Diabetol · 2021 · PMC8120812 · PMID 33985506

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showed a trendno p-value reported

First, two randomized controlled trials, the large Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack (ALLHAT) and the Intervention as a Goal in Hypertension Treatment (INSIGHT) trials showed a trend towards a higher rate of PAD-related events with chlorthalidone and co-amilozide respectively compared to non-diuretic blood pressure lowering treatments [ 5 , 6 ].

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