A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.

J Biol Chem · 2021 · PMC8121974 · PMID 33823155

Europe PMC DOI

hedged sentence

0.1300

closest p · 2.6× alpha

0.1300

boldest claim

The sentences

showed a trendp = 0.13not close (p > 0.1)

p16-L16R patients without cancer (20% growth per day) showed a trend ( p = 0.13 in two-tailed t -tests) toward higher growth rates than WT cells, supporting the idea that p16-L16R increases growth rates, even in subjects without cancer.

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