All of these studies found that patients with a worse WMH burden had lower CBF than those with a less severe WMH burden ( 20 , 31 , 33 , 34 ), one study showed that worse PVWMH, DWMH and whole-brain WMH each showed a trend to be associated with lower CBF both in patients with AD and controls without AD ( n = 203) ( 20 ).
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Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis.
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