Transsynaptic modulation of presynaptic short-term plasticity in hippocampal mossy fiber synapses.

Interestingly, treatment with concanamycin A led to a moderate but highly significant recovery of PTP induced by pre-postsynaptic AP pairing (267.5 ± 40.5%; 246.8 ± 62.5 pA in control versus 554.2 ± 112.3 pA after HFS 100 ; P = 0.003; 12 pairs; Fig. 4g–i ).

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The magnitude of PTP was slightly larger than that in the presynaptic HFS 100 + postsynaptic HFS 100 experiments, but the difference did not reach statistical significance (0.1 mM EGTA post ; P = 0.067; Fig. 2g ).

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