Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer.

Invest Ophthalmol Vis Sci · 2021 · PMC8132000 · PMID 33988693

Europe PMC DOI

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closest p · 1.2× alpha

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showed a trendP = 0.06so close (0.05 < p ≤ 0.1)

While sufficient material was available in only a small number of cases, western blot analysis of protein extracts from affected ( n = 4) and control cases ( n = 3) showed a trend toward reduced WNT10A expression in keratoconus patients (ratio: 0.07, P = 0.06; Figs. 2 B, 2 C).

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