When dichotomizing age at the median (62 years), sNfL was perceived as useful in 60% of the youngest half of the cohort and in 48% of the oldest half of the cohort, which was borderline significant ( p = 0.051, Fig. 1 c).
Perceived usefulness of serum NfL in relation to diagnosis Serum NfL was more often perceived as useful in patients with a diagnosis of psychiatric disorder (71%) or SCD (64%) in comparison to a diagnosis of AD (45%); however, these differences did not reach statistical significance, also not when corrected for age and gender (Fig. 2 c).