Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration.

In terms of structural damage, both the number and area of gaps between cells were increased by the glutamate treatment, and coculture with BACE1-inhibited astrocytes significantly reduced only the number of gaps ( Figure 7C ), although there was an evident trend toward decreased gap area ( Figure 7D ).

also in 268 other papers

The IL-1β immunoreactivity showed a clear trend to decrease, although this trend was not significant, whereas the BACE1 protein levels decreased significantly to the baseline levels observed in the controls ( Figures 6C,D ).

also in 19,460 other papers