The human tRNA-guanine transglycosylase displays promiscuous nucleobase preference but strict tRNA specificity.

Nucleic Acids Res · 2021 · PMC8136771 · PMID 34009357

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a clear trendno p-value reported

Amides are less electron-withdrawing than esters— 15 is an inferior substrate to 13 —and a clear trend exists of diminishing substrate competency as the steric bulk of the amide is increased (i.e. 15 – 20 ).

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