DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.

Additional SNPs were also sequenced at candidate loci on chromosome 9 (rs29890894) and chromosome 15 (rs31781085), which were previously judged to have a potential genetic influence on commissure size based on LOD scores that did not reach statistical significance ( Jones-Davis et al., 2013 ).

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Given the multifactorial nature of CCD in this model, which could incorporate multiple modulatory genetic factors (as additional QTL have appeared promising but failed to reach significance in either Jones-Davis et al. 2013 or our current study), and multiple cellular factors (MZG, leptomeninges, axon plasticity), we anticipate that such a neat outcome would be unlikely and any measures of cellular phenotypes for a given genotype will fall into a distribution without clear boundaries between expected subgroups.

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