Tofacitinib downregulates antiviral immune defence in keratinocytes and reduces T cell activation.

Looking at the gene expression, we found a slight trend towards RORC gene expression, which is associated with classical (less pathogenic) T H 17 cells [ 35 ].

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The pre-treatment with tofacitinib before the addition of LPS led to a strong trend in the reduction of OAS2 expression (Supplemental Fig. 6 b).

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