reached borderline significanceP = 0.051
Addition of biomarkers resulted in significantly improved discriminatory ability ( C -index 0.83, Δ C 0.032; 95% CI 0.015–0.049; P < 0.001) and the addition of the PRS reached borderline significance ( C -index 0.82, Δ C 0.020; 95% CI 0.000–0.040; P = 0.051).