A Non-APOE Polygenic Risk Score for Alzheimer's Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds.

J Gerontol A Biol Sci Med Sci · 2021 · PMC8140047 · PMID 33512503

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

approached significancep = .09so close (0.05 < p ≤ 0.1)

The interactions between APOE ε4 status and the 5e −8 PRS in relation to Aβ42 only approached significance (total sample: p = .09, CDR = 0 subsample: p = .1), but similar to results for the 39-SNP PRS, stratification based on ε4 status showed an association in ε4 carriers in the total sample (β = −56.1, SE = 22.6 p = .02), and a borderline association in the CDR = 0 subsample (β = −48.3, SE = 25.1, p = .06).

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