Cytoplasmic FUS triggers early behavioral alterations linked to cortical neuronal hyperactivity and inhibitory synaptic defects.

Interestingly, 4-months-old Fus ΔNLS/+ mice showed a trend towards longer interaction with the intruder mouse as compared with Fus +/+ mice ( p = 0.07) (Fig. 2a ), that was significant at 10 months of age (Fig. 2b ) and persisted until 22 months of age (Fig. 2c ).

also in 53,322 other papers

Only a nonsignificant trend for reduced volume was detected for hippocampus (9.06% for Fus + /+ vs. 8.62% for Fus ΔNLS/+ ; p = 0.15; Two-sided Unpaired Student’s t -test) and striatum (9.76% for Fus + /+ vs. 9.89% for Fus ΔNLS/+ ; p = 0.56, Two-sided Unpaired Student’s t -test).

also in 5,406 other papers