Preliminary analyses of scRNA sequencing and immunohistochemistry of children's lung tissues indicate the expression of SARS-CoV-2 entry-related genes may not be the key reason for the milder syndromes of COVID-19 in children.

Clin Transl Med · 2021 · PMC8140187 · PMID 34047474

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did not reach statistical significanceno p-value reported

However, both TMPRSS2 and FURIN showed higher expression levels in children compared to adults, although the former did not reach statistical significance possibly due to the small sample sizes available (Figures 2A and 2B ).

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