Identifying Susceptibility Loci for Cutaneous Squamous Cell Carcinoma Using a Fast Sequence Kernel Association Test.

Front Genet · 2021 · PMC8141858 · PMID 34040636

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp = 5.05 × 10 –9actually significant

The association was highly significant in “OncoArray” population ( p = 5.05 × 10 –9 ) and was replicated in “HumanCore” population ( p = 3.73 × 10 –3 ).

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marginally significantno p-value reported

nominally significantno p-value reported

In particular, the association for region SPATA2L was marginally significant in “OmniExpress” and was also nominally significant in both “Illumina” and “OncoArray.” Cross-Check With Expression Quantitative Trait Loci (eQTL) Database To provide additional insights on the possible involvement of these identified regions in regulating gene expression, we summarized the number of known eQTLs within each region ( Table 8 ).

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