Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma.

The combination treatment appeared to increase the levels of conjugated LC3-II as well as p62/SQSTM1 further, pointing towards autophagic flux induction through HDAC inhibitor treatment, which, if late stage fusion is blocked, enhances accumulation of autophagosomes albeit the effect did not reach statistical significance over three experimental replicates ( Figure 1 a; Supplementary Figure S1a,b ).

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