Hyperpolarized ¹³C Magnetic Resonance Spectroscopic Imaging of Pyruvate Metabolism in Murine Breast Cancer Models of Different Metastatic Potential.

Conclusions Consistent with in vitro studies, hyperpolarized [1- 13 C]pyruvate MRSI measures of in vivo glycolytic flux, namely, k PL and AUC L/P , exhibited an increasing trend between metastatic dormant (4T07) and highly metastatic (4T1) murine breast cancer models, although differences were not statistically significant.

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Differences in k PL and AUC L/P did not reach statistical significance, suggesting similar pyruvate utilization in glycolysis for in vivo tumors, similar to in vitro findings using Seahorse flux analysis for the 4T1 and 4T07 cell lines [ 15 ].

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Finally, an unexpected trend observed in the present work was the tendency for blood glucose concentrations to be lower in the metastatic 4T1 tumor-bearing mice than the metastatic dormant 4T07 mouse models despite both sets of mice being consistently fasted for the same amount of time prior to imaging.

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Interestingly, there was a significant positive correlation between AUC L/P and tumor LDH activity, and an observed trend towards higher AUC L/P measures in the more metastatic 4T1 tumor model, but no significant differences were found in tumor LDH activity between the 4T07 and 4T1 tumors.

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