β-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice.

The results were more variable ( Figure S1 F) and did not reach statistical significance, possibly due to known effects of the estrus cycle on anxiety-related behaviors and anxiolytics’ efficacy. 16 We used the male mice data and FDA recommendations 17 , 18 to calculate the human equivalent dose (HED) as 486 mg and the recommended starting dose as 48.6 mg (considering a standard body weight of 60 kg).

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