Integration of Spatial PD-L1 Expression with the Tumor Immune Microenvironment Outperforms Standard PD-L1 Scoring in Outcome Prediction of Urothelial Cancer Patients.

Patients with high PD-L1 expression on IC showed a trend for improved survival as assessed by IC area 25% alone ( Figure 2 D; not significant in multivariable survival models) and significantly improved DSS (5-year DSS rate: 61%; HR mult = 0.44 [95%-CI = 0.27–0.72]) and DFS (5-year DFS rate: 58%; HR mult = 0.42 [95%-CI = 0.26–0.68]) as assessed by Ventana IC5% ( Figure 2 E).

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This is also reflected by the borderline significance of PD-L1 expression in multi-variable adjusted survival analyses in this study [ 36 ].

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