Combined Administration of Fibrinogen and Factor XIII Concentrate Does Not Improve Dilutional Coagulopathy Superiorly Than Sole Fibrinogen Therapy: Results of an In-Vitro Thrombelastographic Study.

Compared to the isolated administration of fibrinogen, the combined treatment with fibrinogen/FXIII led to improved FIBTEM and EXTEM MCF, but failed to reach statistical significance, whereas APTEM MCF showed significant improvement after combined fibrinogen/FXIII-treatment in 20% dilution (FIBTEM: p = 0.1; EXTEM: p = 0.36; APTEM: p < 0.01; Table 2 , Figure 2 ).

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