The results observed with the SAHA-treated A2780 cells were quite significant, because HDACI was able to increase both p21 WAF1/CIP1 and p27 Kip1 levels even though the MDMX, MDM2, and p53 levels were decreasing compared to the control A2780 cells.
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Effect of the HDAC Inhibitor on Histone Acetylation and Methyltransferases in A2780 Ovarian Cancer Cells.
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