The noncoding MIR100HG RNA enhances the autocrine function of transforming growth factor β signaling.

After removing 54 common predicted targets of let-7a-5p and let-7a-2–3p , we observed several highly significant pathways encompassing the target mRNAs, including glycosaminoglycan biosynthetic enzymes, Wnt signaling components, and histone methyltransferases (Supplementary Fig.

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Furthermore, ectopic let-7a-2–3p mimic, enforced significant cell cycle arrest, whereas miR-125b-5p mimic and miR-125b-1–3p mimic showed a trend but not significant effect (Supplementary Fig.

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