Methylation and Expression of <i>FTO</i> and <i>PLAG1</i> Genes in Childhood Obesity: Insight into Anthropometric Parameters and Glucose-Lipid Metabolism.

Spearman’s Correlation Results of Methylation Level and Expression of FTO Gene and PLAG1 Gene In the case of the FTO gene, Spearman’s correlation coefficient r between the methylation level of region 1 with gene’s expression is r = 0.381, with a borderline significance p = 0.055.

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Correlation with other examined parameters (total cholesterol, LDL, HDL, free fatty acids OGTT 60 min and 120 min, glucose-OGTT 60 min and 120 min) did not reach statistical significance ( Table S3 in Supplementary materials ).

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Multiple linear regression analysis revealed that increase in FTO expression is independently associated with growing values of BMI (kg/m 2 , percentile and SDS), waist circumference (cm, percentile), BF_kg, BF_%, and FFA levels; FTO methylation correlates positively with waist circumference (cm) and BF_kg; whereas higher PLAG1 expression predicts elevation of BF_% and FFA levels (the latter of borderline significance). 4.1.

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