Potential Role of Methotrexate Polyglutamates in Therapeutic Drug Monitoring for Pediatric Inflammatory Bowel Disease.

Pharmaceuticals (Basel) · 2021 · PMC8156207 · PMID 34069031

Europe PMC DOI

hedged sentences

0.0660

closest p · 1.3× alpha

0.0660

boldest claim

The sentences

did not reach statistical significancep = 0.066so close (0.05 < p ≤ 0.1)

Although our observation of higher short-chain MTX-Glu levels in CD in remission compared to active CD did not reach statistical significance ( p = 0.066), this is likely due to limitations in the sample size and further obscured by participants receiving concomitant IFX therapy, as suggested by our multivariable regression analysis.

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a positive trendp = 0.066so close (0.05 < p ≤ 0.1)

Looking only at children with Crohn’s disease ( n = 19), a positive trend toward higher short-chain MTX-Glu n concentrations was observed in children with remission vs. active disease, approaching statistical significance ( p = 0.066).

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