Primary outcomes were initially centred around clinical and microbiological markers, but in recent years, there has been an increasing trend towards mortality being the primary outcome.
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Equity in clinical trials for HIV-associated cryptococcal meningitis: A systematic review of global representation and inclusion of patients and researchers.
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With the change in location from HICs to LMICs, there has been a significant trend for authors to be nonnationals of the country where research is performed, particularly in first and senior author positions.