Patients with COVID-19 who died had higher plasma sC5b-9 levels [751.4 (565.2 – 1,115) ng/mL, N=30] compared to those who survived the index hospitalization, although this did not reach statistical significance [600.0 (349.9 – 858.5) ng/mL, N=104, p=0.0666, Fig. 2C ].
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Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection.
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0.0666