<i>ACTB</i> Methylation in Blood as a Potential Marker for the Pre-clinical Detection of Stroke: A Prospective Nested Case-Control Study.

Overall, there was a clear trend of decreasing in OR per + 10% methylation of ACTB_CpG_14 and -log 1 0 P -value in stroke cases with onset time <2, ≤1.5, ≤1.32, and ≤1 year ( Figures 1E,F ).

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Results We observed a highly significant correlation between hypomethylation of one CpG site of ACTB and increased risk of stroke in an onset-time-dependent manner (for onset time ≤ 1.5 years: odds ratio (OR) per + 10% methylation = 0.76, P = 0.001; for onset time ≤ 1.32 years: OR per + 10% methylation = 0.59, P = 7.82 × 10 –7 ; for onset time ≤ 1 year: OR per + 10% methylation = 0.43, P = 3.00 × 10 –6 ), and the increased cumulative incidence of stroke (log-rank P = 3.13 × 10 –7 ).

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