Response Rate and Survival at Key Timepoints With PD-1 Blockade vs Chemotherapy in PD-L1 Subgroups: Meta-Analysis of Metastatic NSCLC Trials.

Compared with docetaxel in previously treated patients, which was associated with a response rate of 11.3% (95% CI = 9.9% to 12.7%), the ORR was higher with PD-1 blockade in the PD-L1 1%-49% ( P = .03) and 50% or greater ( P < .001) subgroups, whereas comparison between these treatment options in the PD-L1 less than 1% subgroup did not reach statistical significance. 1-Year and 2-Year PFS in PD-L1 Less Than 1%, 1%-49%, and 50% or Greater Subgroups First-line PD-1 blockade was associated with 1-year PFS and 2-year PFS rates of 40.3% (95% CI = 36.6% to 44.0%) and 24.6% (95% CI = 20.8% to 28.3%), respectively, if PD-L1 was equal to 50% or greater; rates of 35.0% (95% CI = 22.0% to 48.0%) and 16.6% (95% CI = 6.5% to 26.7%) if PD-L1 was equal to 1%-49%; and 19.9% (95% CI = 4.7% to 35.2%) and no data for 2-year PFS if PD-L1 was less than 1% ( Figure 3, A and C ).

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