Urine concentrating defect as presenting sign of progressive renal failure in Bardet-Biedl syndrome patients.

Clin Kidney J · 2021 · PMC8162863 · PMID 34084454

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showed a trendno p-value reported

Conversely, truncating mutations affected max-Uosm and showed a trend towards a reduction in eGFR.

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an increasing trendno p-value reported

Moreover, the evidence that u-AQP2 excretion has an increasing trend suggests possible compensatory ADH overproduction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.