Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration.

Neurology · 2021 · PMC8166434 · PMID 33827960

Europe PMC DOI

hedged sentence

0.0850

closest p · 1.7× alpha

0.0850

boldest claim

The sentences

did not reach statistical significancep = 0.085so close (0.05 < p ≤ 0.1)

Median plasma NfL concentrations tended to be higher in those with MBI/MCI than asymptomatic mutation carriers, but the results did not reach statistical significance (12.2 ± 10 pg/mL vs 7.5 ± 6 pg/mL, p = 0.085, mean estimate difference 0.44, 95% confidence interval [CI] 0.85–0.99, p = 0.016) in all genotypes combined.

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