Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology.

Enzyme-linked immunosorbent assay (ELISA) on postmortem brain tissues from eleven subjects with mild CTE showed an increasing trend in NUP62 levels, although they were not significantly different from controls cases.

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Further, Nup93-2 and Nup44A overexpressing flies showed a trend of decreasing nuclear Tbph intensity that was not significant ( Figure 4—figure supplement 3C ). qPCR analysis validated that flies significantly overexpressed Nup93-2 and Nup44A mRNA ( Figure 4—figure supplement 3D,E , p < 0.001).

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