a nonsignificant trendp = 0.052
Significant positive correlations were also found between baseline CLU levels and the DAS28 at months 3 and 12 (r = 0.346, p = 0.012; r = 0.367, p = 0.007, respectively); however, the correlation at month 6 showed only a nonsignificant trend towards a positive association (r = 0.271, p = 0.052) (Fig. 2 ).