Additionally, low ETI exposure correlated with increased connectivity approaching significance between default mode (precuneus) and sensorimotor (precentral gyrus (q = 0.054)). 3.5 Early life adversity correlates with alterations in the brain-gut-microbiome system and current mood symptoms Significant relationships were identified between the significant pairs of connected brain regions (Section 4.3 ), four metabolites (glutamate gamma-methyl ester, 5-oxoproline, malate, and urate; Section 4.2 ), and four clinical variables (ETI score, PSS score, HADS anxiety, and HADS depression; Section 4.1 ) ( Table 4 ; Fig. 4 ).
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Early life adversity predicts brain-gut alterations associated with increased stress and mood.
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