Effects of pre-analytical procedures on blood biomarkers for Alzheimer's pathophysiology, glial activation, and neurodegeneration.

Alzheimers Dement (Amst) · 2021 · PMC8171159 · PMID 34124336

Europe PMC DOI

hedged sentences

0.0010

closest p · 0.0× alpha

0.0650

boldest claim

The sentences

highly significantP < .001actually significant

Blood t‐tau and p‐tau181 demonstrated differences between tube types, including highly significant changes between serum and LiHep (Figure 2G–H , both P < .001).

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approaching significanceP = .065so close (0.05 < p ≤ 0.1)

Mean concentrations of EDTA and serum for p‐tau181 decreased over freeze–thaw cycles but reached statistical difference at freeze–thaw cycle 4 for plasma ( P < .01) but not serum; however, serum p‐tau181 freeze–thaw cycle 4 was approaching significance ( P = .065, Figure 5H ). 4.

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