Prohibitin 1 is essential to preserve mitochondria and myelin integrity in Schwann cells.

Nat Commun · 2021 · PMC8172551 · PMID 34078899

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In line with our morphological findings, Phb1-SCKO animals treated with ISRIB showed a trend toward reduced performance in the rotarod test as compared to Phb1-SCKO mice treated with vehicle (p-values Phb1-SCKO + ISRIB vs Phb1-SCKO + Veh: Day 2 = 0.0936, Day 3 = 0.0979, Day 4 = 0.0723) (Fig. 7f ).

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