Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort.

Clin Transl Allergy · 2021 · PMC8173588 · PMID 33900052

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clearly significantno p-value reported

8 , 20 , 21 , 22 , 23 , 24 Patients included in this, the MEGA study, showed a clearly significant association between severe asthma on the one hand and increased symptoms and exacerbations, lower disease control, greater airflow obstruction and higher frequency of CRSwNP, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis on the other when compared to patients with milder disease.

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