Tight nanoscale clustering of Fcγ receptors using DNA origami promotes phagocytosis.

This differential recruitment of downstream signaling molecules to 4T versus 4S origami beads was most apparent in early and mid-stage phagocytic cups; late-stage cups showed only a slightly significant difference in tSH2-Syk recruitment and no significant differences in generation of PIP 3 or actin filaments ( Figure 6—figure supplement 1 ).

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