Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia.

Eur J Nucl Med Mol Imaging · 2021 · PMC8175302 · PMID 33521872

Europe PMC DOI

hedged sentences

0.1100

closest p · 2.2× alpha

0.1100

boldest claim

The sentences

showed a trendp = 0.11not close (p > 0.1)

APOE-ε4 showed a trend towards increased tau accumulation over time in Braak-V/VI compared to APOE-ε3 homozygotes (β std [95%CI]: 0.10 [− 0.02, 0.18], p = 0.11), and this association was fully mediated by baseline Aβ.

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marginally significantno p-value reported

However, the study reported a marginally significant independent APOE-ε4 effect on higher tau accumulation rates in a group of cognitively impaired individuals, but the interpretation of this finding is complicated by the mixed clinical composition of this group that included patients with MCI as well as typical and atypical AD dementia phenotypes.

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a trend towards significanceno p-value reported

Mediation analyses were only performed on the associations that were significant or showed a trend towards significance in the previous analysis.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.