Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients.

In a second, independent study sample of 50 patients who underwent amitriptyline therapy of 75 mg twice daily, a significant trend of increasing amitriptyline plasma concentrations with decreasing OCT1 activity was observed ( p = 0.018), while nortriptyline plasma concentrations were unaffected by the OCT1 genotype.

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Multiple linear regression analysis showed significant effects for OCT1 and CYP2C19 on AT and highly significant effects for CYP2D6 on NT mean plasma concentrations per dose unit ( Table 7 ).

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