Germline nuclear-predominant Pten murine model exhibits impaired social and perseverative behavior, microglial activation, and increased oxytocinergic activity.

We found a near-significant trend toward an increase in call frequency from Pten Y68H/ + pups separated from mothers compared to littermate controls ( P = 0.057), suggesting greater anxiety in Pten Y68H/ + mice (Fig. 2 l).

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