The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression.

In FSL animals, both alcohol exposure and OSU administration had significant main effects on latency-to-approach, with post-hoc assessments showing a significant difference between OSU and vehicle in the alcohol-naïve group, and a close-to-significant difference in the alcohol group [Fig. 5 a; Mixed-effects model: Alcohol treatment, F(1, 18) = 5.13, P = 0.03; OSU treatment, F(1, 15) = 13.61, P = 0.002, Interaction, F(1, 15) = 0.40, P = 0.53; Sidak's multiple comparisons test, Vehicle—OSU6162: Alcohol-naïve group, P = 0.01; Alcohol group, P = 0.08].

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