The correlation between mutated TP53 status and liquid biopsy positivity became highly significant at the time of disease progression, when the TP53 results of liquid biopsies were also considered (69% vs. 19%, P<0.001, Table 1 ).
In addition, presence of TP53 mutations at initial diagnosis as detected by tissue DNA-NGS, showed a trend for association with subsequent liquid biopsy positivity (baseline TP53 mutations in 33% vs. 19% of subsequently liquid biopsy-positive vs. negative cases, P=0.068, Table 1 ).